Blood Clots Could Be the Root Explanation for All Coronary heart Illness

Editor’s Observe: This text is a reprint. It was initially printed February 13, 2022.

On this interview, repeat visitor Dr. Malcolm Kendrick, a board-certified household doctor and writer of the e book, “The Clot Thickens: The Enduring Thriller of Coronary heart Illness,” evaluations the underlying mechanisms for coronary heart illness, which for the final century has been the main explanation for demise within the U.S.

Of all of the books he is written, that is my favourite, because it goes into nice element, providing you with the organic understanding of the method of atherosclerosis resulting in coronary heart assaults and strokes. He additionally has strong methods for decreasing your heart problems threat.

By the way, when you perceive the illness course of, then you may as well perceive how each COVID-19 and the COVID jab can contribute to coronary heart illness. When requested why he is taken such an curiosity in coronary heart illness, Kendrick replies:

“After I was coaching as a pupil in drugs, Scotland had the best charge of coronary heart illness on the planet. Early on the reply for why was, ‘Oh, nicely, it is as a result of we now have such horrible food plan, and we eat garbage meals like deep fried Mars bars.’

So, you eat an excessive amount of saturated fats, the saturated fats will get become ldl cholesterol in your bloodstream, after which it is absorbed into arteries and varieties narrowings and thickenings, which all sounds believable for those who do not give it some thought too laborious.

However I additionally occur to go to France quite a bit, and what I observed about France was, they eat a number of saturated fats. They eat extra, actually, than anybody else in Europe, and definitely greater than Scotland. So, [this saturated fat] speculation actually did not work for the French. They’ve the best saturated fats consumption in Europe and lowest charge of coronary heart illness, and this has been the case for many years.

If you happen to took all the danger elements for France and Scotland [such as smoking, high blood pressure and diabetes], then the French had barely [higher risk], in accordance with typical pondering. However, actually, that they had one-fifth [the rate among age-matched men].

So, I believed, that is attention-grabbing. It does not make a lot sense in accordance with what we’re informed. Then whereas I used to be in medical faculty, a tutor in cardiology mentioned … LDL can not cross the endothelium. On the time, I did not know what LDL was, nor did I do know what the endothelium was, nevertheless it sounded necessary.

She had been taking a look at coronary heart illness as a special course of for many years … So, I believe that is actually the place I bought began. When you begin questioning what the issue is, you find yourself questioning increasingly and also you begin pondering, gosh, that is simply nonsense, is not it? This complete speculation is simply nonsense. So, I began choosing it aside.”

The Thrombogenic Speculation

“The Clot Thickens” is Kendrick’s effort to elucidate another speculation for what really causes coronary heart illness. If it is not saturated fats and ldl cholesterol, what’s it? In 1852, a Viennese researcher, Karl von Rokitansky, developed what he known as the encrustation speculation of coronary heart illness.

Right now, this speculation has been renamed the thrombogenic speculation. “Thrombo” stands for thrombosis, i.e., blood clots, and “genesis” means the reason for, or the beginning of. So, the thrombogenic speculation is that blood clots are the fundamental pathology that causes all coronary heart illness.

In a nutshell, when a blood clot varieties in your artery wall, which may occur for plenty of causes, it can sometimes be coated over and dissolved. An issue arises, nevertheless, if the blood clot will not be totally eradicated and one other blood clot varieties in the identical “weak” space. This then turns into what’s conventionally known as atherosclerotic plaque.

“The atherosclerotic plaque is principally a buildup of blood clot, restore, blood clot, restore, blood clot, restore,” Kendrick explains. “If the blood clotting course of is quicker than the restore course of, you may have a plaque that step by step grows and finally thickens the artery wall till it narrows sufficiently that the ultimate blood clot, on prime of the prevailing plaque, is the factor that may trigger a coronary heart assault or stroke …

If you happen to minimize via the plaque and take a look at it, it virtually appears like tree rings. You’ll be able to see there’s been a clot, restore, clot, restore, clot, restore, clock, restore over time.

It is broadly accepted {that a} blood clot forming on an current plaque will trigger the plaque to develop in dimension. Yow will discover 10,000 papers saying that that is the case. What the mainstream will not settle for is {that a} blood clot on a wholesome artery wall can provoke the entire course of.

So, to an extent, all I am saying to individuals is, nicely, we all know blood clots trigger the ultimate occasion. We all know blood clots trigger plaques to develop. Why will not you settle for that blood clots are the factor that begins it within the first place? As a result of then we now have one course of all over, and it is sensible, as a result of it suits with what you possibly can see.”

As famous by Kendrick, the standard view is that low-density lipoprotein or LDL will get into the artery wall the place it initiates plaque formation. It then, inexplicably, stops initiating plaque, and the plaque continues to develop via the addition of repeated clots.

Nonetheless, Kendrick says, when you begin drilling down into the ldl cholesterol, aka LDL speculation, the entire thing begins to disintegrate. LDL merely can not clarify the illness development. But regardless of the various holes within the idea, the concept LDL causes coronary heart illness is touted as an absolute, proven fact.

What is the Mechanism?

As a way to justify a speculation, you could have a mechanism of motion. When you perceive the mechanism of the particular illness course of, then you possibly can put the puzzle items collectively. Kendrick begins his clarification:

“Your blood vessels are lined with endothelial cells, a bit like tiles on a wall. Endothelial cells are additionally coated themselves in a factor known as glycocalyx. If you happen to attempt to choose up a fish, it’s going to slip via your fingers; it is very slippery. The explanation it is slippery is as a result of it is coated in glycocalyx and the glycocalyx is extremely slippery. It is nature’s Teflon.

So principally, in our case, the glycocalyx [is inside] our blood vessels, to permit the blood to journey via with out it sticking, with out injury occurring. So, you may have this type of damage-repellent layer on prime of your endothelial cells.

Now, if that layer is broken, after which the endothelial cell itself beneath is broken, then the physique will say, ‘Oh, we have got injury to a blood vessel, we should have a blood clot there as a result of we may bleed out.’ So, a blood clot varieties on the realm of injury, and instantly stops [the bleeding].”

The blood clot does not simply carry on rising and rising. If it did, you’d die anytime you had a blood clot. As a substitute, when a clot varieties, different processes step in to stop it getting too massive, which is why each blood clot does not trigger a stroke or coronary heart assault. As soon as the clot has stabilized, and has been shaved down, the realm is roofed over by endothelial progenitor cells, made within the bone marrow, that float round in your blood stream.

When a progenitor cell finds an space that has been broken, it attaches itself to that space, together with others, forming a brand new endothelial layer. The remaining blood clot is now mendacity “inside” the artery wall itself. So, principally, it is the restore course of that may result in plaque buildup inside the artery wall. In time, if injury outstrips restore, this may slender the artery and cut back blood circulate.

What Damages Endothelial Cells?

The query is, what can injury the endothelium within the first place? Right here, Kendrick makes use of the SARS-CoV-2 mechanism for instance:

“The COVID virus enters endothelial cells via the ACE2 receptor. It prefers endothelial cells as a result of they have ACE2 receptors on them. It will get into the endothelial cell and begins replicating, then bursts out, damaging the cell. Bingo, you’ve got bought an space of injury.

After all, added to this, when cells have viruses inside them, they ship out misery alerts to the immune system saying, ‘I have been contaminated, come and kill me,’ and so the immune system begins to have a go on the endothelial cells. That is why you may get an issue, as a result of the endothelial cells are being broken and stripped off.

Blood clotting happens on the factors of injury and hey, presto, you are having clotting, you are having strokes, you are having coronary heart assaults, which is the factor that folks at first could not perceive [about COVID-19]. But it is very clear that what’s taking place is you’ve got bought injury to the endothelial cells.

Clearly, you and I each know that for those who get a [COVID jab], the cells are triggered to provide the spike protein, and these cells are sending out misery messages saying, ‘I am contaminated.’ It’s important to be very cautious if you wish to stick one thing into cells that then says to the immune system, ‘Please come and destroy me,’ as a result of that is what the immune system goes to do.

However shifting on from that, what different factor may cause endothelial injury? The reply is issues like smoking. Smoke particles get out of your lungs, they go into your blood vessels and so they trigger injury … You smoke one cigarette and an entire bunch of microparticles seem in your bloodstream, which implies endothelial cells are dying.

Fortunately as endothelial cells die, one other message is shipped to the bone marrow saying, we’d like extra endothelial cells and it stimulates endothelial progenitor cell manufacturing. These endothelial progenitor cells rush round protecting over the areas of injury.

Some people who smoke have sufficient restore happening and if you’re youthful, it is okay. As you grow old and your restore techniques start to fail a bit, cigarette smoking turns into increasingly of an issue.”

Different issues that may trigger endothelial injury embody:

Repairing the Glycocalyx

As defined by Kendrick, the glycocalyx layer resembles a garden, with slippery filaments that stick up. Inside this glycocalyx layer you may have nitric oxide synthase (NOS), which produces nitric oxide (NO), and you’ve got NO itself, in addition to plenty of different anticoagulant proteins. The glycocalyx is definitely a potent anticoagulant layer, so it stops blood clots forming. If glycocalyx is broken, your threat of blood clotting will increase.

“It is a very difficult layer,” Kendrick says. “It is like a jungle filled with issues that say, ‘Do not follow this, avoid this.'” Inside it, you even have albumin, protein advanced produced by the liver. Albumin incorporates the proteins that assist keep and restore the glycocalyx. A truth that almost all docs are unaware of is that, if in case you have a low albumin stage, you are considerably extra prone to die of coronary heart illness.

The excellent news is that whereas the glycocalyx layer may be quickly destroyed, it will also be quickly repaired. (Experiments have proven that in an space the place the glycocalyx has been utterly stripped off, it may be utterly repaired in a single second.) Dietary supplements like chondroitin sulfate and methylsulfonylmethane (MSM) may be useful on this regard.

“If you happen to try to clarify that via the LDL mechanism, it simply does not work,” Kendrick says. “They’ve found that for those who give chondroitin sulfate as a complement — which usually is for arthritis and stuff like that — it reduces the danger of coronary heart illness fairly significantly. How do you clarify that? Effectively, you possibly can clarify that since you’re defending your glycocalyx.

These are the type of issues that make no sense for those who like wanting on the typical concepts of coronary heart illness, however are instantly and simply defined for those who say, ‘We’ve to maintain our glycocalyx wholesome and we now have to maintain our endothelial cells beneath them wholesome.’

In any other case they are going to be broken and stripped off, after which we’ll get a blood clot, and if we preserve getting blood clots at that time, we’ll find yourself with a plaque and finally one of many blood clots on that plaque will kill you from a coronary heart assault or a stroke.”

Blood Stream Restriction Coaching

A life-style technique that may assist restore endothelial injury is blood circulate restriction (BFR) coaching. In response to BFR, your physique produces vascular endothelial progress issue (VEGF), which acts as “fertilizer” for the endothelium. You’ll be able to study the ins and outs of BFR in my free BFR report. VEGF additionally induces the synthesis of nitric oxide (NO), a potent vasodilator, and it stimulates endothelial progenitor cells.

“NO protects the endothelium. It’s anticoagulant — essentially the most potent anticoagulant we now have within the physique. It is actually the magic molecule for cardiovascular well being,” Kendrick says.

“At one time NO was often known as Endothelial Derived Rest Issue (EDRF) NO was one thing nobody believed may presumably exist within the human physique. NO is definitely a free radical. Everybody says free radicals are terribly damaging and unhealthy.

To that I reply, ‘Effectively, it’s possible you’ll want to know that the chemical that’s the single most necessary protecting chemical within the physique for the cardiovascular system is an extremely free radical known as nitric oxide.'”

Some anticancer medication are designed to dam VEGF, because the tumor wants angiogenesis — which is the creation of recent blood vessels which can be required to offer ample “vitamins” With out these new blood vessels, the tumor dies off. Sadly, for those who block VEGF, you additionally block NO, which then raises your threat for coronary heart illness.

“These medication have been virtually faraway from the market,” Kendrick says, “as a result of regardless of their anticancer exercise, they have been procardiovascular illness to fairly a scary diploma.

[That’s why], if you’re given bevacizumab or Avastin as an anticancer drug, they now offer you angiotensin changing enzyme inhibitors (ACE inhibitors), that are blood strain decreasing tablets, and ACE inhibitors have a particular influence on bradykinin, which will increase NO synthesis.”

Methods to Decrease Your Thrombotic Threat

In his e book, “The Clot Thickens: The Enduring Thriller of Coronary heart Illness,” Kendrick evaluations many alternative methods that may decrease your illness threat. Here is a short-list of examples coated in far better depth within the e book, in addition to a few of my very own suggestions that I convey up within the interview: