Final Up to date February 2023
This can be a present record of each examine we’ve discovered on the security and efficacy of hydroxyapatite toothpaste. We created this to be a useful resource for each sufferers and the purposeful dentistry neighborhood, so be at liberty to bookmark it, share it extensively along with your sufferers, and e-mail us if in case you have a examine so as to add.
I have to give credit score to Jacqueline Carcaramo, RDH (@the.flossophy on Instagram) who impressed this concept. Once we each realized we had been preserving our personal repository of research on this subject, we realized we may be a part of forces and publish this database for the advantage of purposeful dentists and hygienists in all places.
Research on Hydroxyapatite Toothpaste Efficacy & Security
Biomimetic hydroxyapatite and caries prevention: a scientific overview and meta-analysis (2021)
Based mostly on this systematic overview and meta-analysis of over 291 research of micro-Hydroxyapatite, the authors concluded there may be good proof that micro-Hydroxyapatite in oral care merchandise within the absence of fluoride successfully reduces caries. They don’t conclude on how a lot micro-Hydroxyapatite is right, however this newer examine (performed after this overview was revealed) mentions it needs to be round 10-15% for micro-Hydroxyapatite.
Dr. B’s Notes: Nice abstract of the literature about nano-hydroxyapatite, particularly the advantages of utilizing nano-hydroxyapatite for its preventive, restorative, and regenerative functions in dentistry. Offers you an thought of the vast utilization of nano-Hydroxyapatite in not solely dentistry, however a variety of functions in drugs as effectively.
Demineralized dentin infiltrated with silica NPs seems to encourage heterogeneous mineralization of the dentin collagen matrix following publicity to a man-made saliva answer.
Reconsidering remineralization methods to incorporate nanoparticle hydroxyapatite.
This in-vitro examine documented the deposition of nanoparticle hydroxyapatite on demineralized enamel surfaces after remedy with an experimental remineralization gel. This discovering helps consideration of an extra strategy to remineralization that features pH neutralization methods and nanoparticle hydroxyapatite crystals.
Impact of nano-hydroxyapatite focus on remineralization of preliminary enamel lesion in vitro (2009)
Dr. B’s notes: That is an older examine out of China which studied 4 completely different concentrations of nano-hydroxyapatite (1%, 5%, 10% and 15% by weight). The ten% and 15% demonstrated efficacy (in different phrases, labored effectively) but it surely’s not clear what sort of nano-Hydroxyapatite was used, together with particle measurement and particle form, sadly. The essential factor to know right here is that the focus of hydroxyapatite was calculated primarily based on weight, not quantity, like toothpaste producers do. So, in actuality, the therapeutic dose is between 1 and three% if calculating by quantity.
Remineralization Potential of Nano-Hydroxyapatite on Preliminary Enamel Lesions: An in vitro Examine (2011)
Dr. B’s Notes: The remineralization impact of nano-Hydroxyapatite elevated considerably when the pH was lower than 7. Why is that this essential? You’re going to listen to lots of people say that for remineralization to happen, pH must be impartial or increased, however this incorrect; the pH should be between 5.5 and 6.5 to ensure that there to be ion trade (on this case, remineralization). The proportion of floor microhardness restoration and built-in mineral loss obtained from CSMH exams demonstrated that nano-HA supplies higher remineralization than micro-HA.
Combined Results of Nano-Hydroxyapatite and NaF on Remineralization of Early Caries Lesion
The intention of this examine was to guage the mixed results of a nano-HA and fluoride mouthrinse on an early caries lesion in human enamel utilizing an in vitro cycle remineralization and remedy mannequin.
Effectiveness of nano-hydroxyapatite toothpaste in lowering dentin hypersensitivity: a double-blind randomized managed trial
A double-blind randomized medical trial that in contrast the efficacy in lowering dentin hypersensitivity of a dentifrice formulation containing nano-hydroxyapatite with a fluoride dentifrice and a placebo.
Nano-HA and NAF mouthrinses can enormously improve remineralization and improve tooth microhardness.
Remineralization Potential of New Toothpaste Containing Nano-Hydroxyapatite
The outcomes confirmed that there have been no vital variations in Vickers Hardness Quantity values between the 2 toothpastes (P>0.05). A toothpaste containing nano-sized hydroxyapatite has the potential to remineralize an incipient caries lesion. As well as, the addition of fluoride had no synergistic impact on remineralization.
Dr. B’s Notes: This examine was carried out in vitro and in vivo—you don’t see that too usually!
Comparison of hydroxyapatite and fluoride oral care gels for remineralization of preliminary caries: a pH-cycling examine (2020)
Dr. B’s notes: Peer-reviewed examine demonstrating 15% micro-Hydroxyapatite-based gel (15% HAP) was as efficient as fluoride-based gel (at 12,500 ppm, which is even stronger than Prevident 5000) in remineralizing preliminary caries lesion.
Enamel and dentine remineralization by nano-hydroxyapatite toothpastes
Toothpastes containing n-HAp revealed increased remineralizing results in comparison with amine fluoride toothpastes with bovine dentine, and comparable tendencies had been obtained for enamel.
Remineralization of early caries by a nano-hydroxyapatite dentifrice
The aim of this randomized, double-blind, crossover, in situ examine was to guage the efficacy of nano-hydroxyapatite (nHAP) dentifrices on caries remineralization and demineralization inhibition. nHAP dentifrice brought about remineralization similar to a fluoride dentifrice, and inhibited caries improvement, thus suggesting that an nHAP dentifrice might be an efficient various to fluoride toothpaste.
Artificial Biomimetic Carbonate-Hydroxyapatite Nanocrystals for Enamel Remineralization (2008)
Dr. B’s Notes: Simply one other early examine out of Italy that helps the concept nano-Hydroxyapatite is nice at remineralizing tooth.
- HApNPs allowed Ca2+ and PO43− launch in low pHs.
- HApNPs allow remineralization of caries-like enamel lesions.
This examine investigated the flexibility of hydroxyapatite nanoparticles (nano-HA) to remineralize enamel, and their impact on sealant microleakage and shear bond energy (SBS).
Nano-hydroxyapatite toothpaste ingredient for tooth remineralization and sensitivity
Bionic results of nano hydroxyapatite dentifrice on demineralised floor of enamel submit orthodontic debonding: in-vivo break up mouth examine
The submit Present Analysis on Hydroxyapatite Toothpaste Efficacy and Security appeared first on Ask the Dentist.
